52 resultados para within-host modelling

em Deakin Research Online - Australia


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Prevailing theory assumes cuckoos lay at random among host nests within a population, although it has been suggested that cuckoos could choose large nests and relatively active pairs within host populations. We tested the hypothesis that egg matching could be improved by cuckoos choosing nests in which host eggs more closely match their own, by assessing matching and monitoring nest fate in great reed warblers naturally or experimentally parasitized by eggs of European cuckoos. A positive correlation between cuckoo and host egg visual features suggests that cuckoos do not lay at random within a population, but choose nests and this improves egg matching: naturally parasitized cuckoo eggs were more similar to host eggs as perceived by humans and as measured by spectrophotometry. Our results suggest a hitherto overlooked step in cuckoo-host evolutionary arms races, and have nontrivial implications for the common experimental practice of artificially parasitizing clutches.

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In nature, hosts are exposed to an assemblage of parasite species that collectively form a complex community within the host. To date, however, our understanding of how within-host–parasite communities assemble and interact remains limited. Using a larval amphibian host (Pacific chorus frog, Pseudacris regilla) and two common trematode parasites (Ribeiroia ondatrae and Echinostoma trivolvis), we experimentally examined how the sequence of host exposure influenced parasite interactions within hosts. While there was no evidence that the parasites interacted when hosts were exposed to both parasites simultaneously, we detected evidence of both intraspecific and interspecific competition when exposures were temporally staggered. However, the strength and outcome of these priority effects depended on the sequence of addition, even after accounting for the fact that parasites added early in host development were more likely to encyst compared to parasites added later. Ribeiroia infection success was reduced by 14 % when Echinostoma was added prior to Ribeiroia, whereas no such effect was noted for Echinostoma when Ribeiroia was added first. Using a novel fluorescent-labeling technique that allowed us to track Ribeiroia infections from different exposure events, we also discovered that, similar to the interspecific interactions, early encysting parasites reduced the encystment success of later arriving parasites by 41 %, which could be mediated by host immune responses and/or competition for space. These results suggest that parasite identity interacts with host immune responses to mediate parasite interactions within the host, such that priority effects may play an important role in structuring parasite communities within hosts. This knowledge can be used to assess host–parasite interactions within natural communities in which environmental conditions can lead to heterogeneity in the timing and composition of host exposure to parasites.

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The paper interrogates the literature on online cultural and religious identities through a critical engagement of Stuart Hall's work on new ethnicity and regimes of representation. It suggests that this literature conflates Hall's notion of ‘new ethnicity’ with one that argues that online cultural and religious identities are ‘new’ because of transnational and global processes, the pervasiveness of computer-mediated communication and the global mobility of immigrants. Thus, current research on online ethnic and religious identities underestimates the complexity of Hall's concept and to highlight this complexity we ponder the extent to which new online ethnicities – as expressed in the current literature – reflect, construct or renegotiate so-called offline ethnicities. The paper concludes that online ethnic subjectivities, while providing alternative representations to counteract the dominant racist discourse within host societies, still reflect mimic essentialist voices.

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Migratory animals are simultaneously challenged by the physiological demands of long-distance movements and the need to avoid natural enemies including parasites and pathogens. The potential for animal migrations to disperse pathogens across large geographic areas has prompted a growing body of research investigating the interactions between migration and infection. However, the phenomenon of animal migration is yet to be incorporated into broader theories in disease ecology. Because migrations may expose animals to a greater number and diversity of pathogens, increase contact rates between hosts, and render them more susceptible to infection via changes to immune function, migration has the potential to generate both "superspreader species" and infection "hotspots". However, migration has also been shown to reduce transmission in some species, by facilitating parasite avoidance ("migratory escape") and weeding out infected individuals ("migratory culling"). This symposium was convened in an effort to characterize more broadly the role that animal migrations play in the dynamics of infectious disease, by integrating a range of approaches and scales across host taxa. We began with questions related to within-host processes, focusing on the consequences of nutritional constraints and strenuous movement for individual immune capability, and of parasite infection for movement capacity. We then scaled-up to between-host processes to identify what types, distances, or patterns of host movements are associated with the spread of infectious agents. Finally, we discussed landscape-scale relationships between migration and infectious disease, and how these may be altered as a result of anthropogenic changes to climate and land use. We are just beginning to scratch the surface of the interactions between infection and animal migrations; yet, with so many migrations now under threat, there is an urgent need to develop a holistic understanding of the potential for migrations to both increase and reduce infection risk.

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In 2002 the State Government of Victoria, in partnership with the City of Greater Geelong and Deakin University, initiated and urban design framework to explore development opportunities of a series of redundant industrial sites adjacent to Geelong's central activities area (CAA). One of the objectives of the framework was to explore a range of initiatives based on the expansion of Deakin University Waterfront campus from 700 students to an expected cohort of 5000 students. Working with a set of predefined constructs for different types of city-based user groups, such as net floor space requirements and time/travel distances between facilities, the following paper presents a simple computational approach to assist in identifying, mapping, and spatially exploring different development scenarios.

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As population change places pressure on expanding regional and metropolitan urban boundaries, so the threat of bushfire at the rural/urban interface increases. This paper presents a range of 2D and 3D 1:40 and full scale modelling investigations. Various relationships are explored between the urban and rural interface with respect to: air pressure; changes in wind pattern; vectorial velocity; and the deposition of hot ash and firebrand deposits around single story building forms, both as standalone and within an orthogonal array and cul-de-sac relationships.

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In the light of the Victorian State Government's move towards the development of 'Plan Melbourne' - a new metropolitan planning strategy currently being prepared to take Melbourne forward to 2050 - the following paper attempts to address the issue of how an inner city target of 90,000 new dwellings (Inner Metropolitan Action Plan - IMAP Strategy 5) will impact on existing inner Melbourne activity centres. Working with the prospect of establishing a more compact city within the inner Melbourne region, the paper will focus on key suburbs within the Port Phillip area. Working with a 'Housing Variance Model' based on household structure and dwelling type, the paper will attempt to assess the impact on urban morphology as capacity is progressively altered through a range of built form permutations.

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Prediction of pedestrians’ steering behaviours within the built environments under normal and non-panic situations is useful for a wide range of applications, which include social science, psychology, architecture, and computer graphics. The main focus is on prediction of the pedestrian walking paths and the influences from the surrounding environment from the engineering point of view.

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The aim of this paper was to see whether all-cause and cause-specific mortality rates vary between Asian ethnic subgroups, and whether overseas born Asian subgroup mortality rate ratios varied by nativity and duration of residence. We used hierarchical Bayesian methods to allow for sparse data in the analysis of linked census-mortality data for 25-75 year old New Zealanders. We found directly standardised posterior all-cause and cardiovascular mortality rates were highest for the Indian ethnic group, significantly so when compared with those of Chinese ethnicity. In contrast, cancer mortality rates were lowest for ethnic Indians. Asian overseas born subgroups have about 70% of the mortality rate of their New Zealand born Asian counterparts, a result that showed little variation by Asian subgroup or cause of death. Within the overseas born population, all-cause mortality rates for migrants living 0-9 years in New Zealand were about 60% of the mortality rate of those living more than 25 years in New Zealand regardless of ethnicity. The corresponding figure for cardiovascular mortality rates was 50%. However, while Chinese cancer mortality rates increased with duration of residence, Indian and Other Asian cancer mortality rates did not. Future research on the mechanisms of worsening of health with increased time spent in the host country is required to improve the understanding of the process, and would assist the policy-makers and health planners.

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The synthesis of the first example of an organotin double ladder (6) containing a functional group within the spacer is reported. In the solid state, compound 6 shows an interlaminar cavity whose size and shape suggest the possibility of host–guest chemistry. 119Sn-NMR and ESMS show that compound 6 undergoes extensive dissociation in solution. ESMS of compound 6 to which have been added Li+, Na+, Mg2+ or Cu2+ show only minimal interaction.


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In the coastal region of south-western Victoria, Australia, populations of native small mammal species are restricted to patches of suitable habitat in a highly fragmented landscape. The size and spatial arrangement of these patches is likely to influence both the occupancy and richness of species at a location. Geographic Information System (GIS)-based habitat models of the species richness of native small mammals, and individual species  occurrences, were developed to produce maps displaying the spatial  configuration of suitable habitat. Models were generated using either generalised linear Poisson regression (for species richness) or logistic regression (for species occurrences) with species richness or  presence/absence as the dependent variable and landscape variables, extracted from both GIS data layers and multi-spectral digital imagery, as the predictor variables. A multi-model inference approach based on the Akaike Information Criterion was used and the resulting model was applied in a GIS framework to extrapolate predicted richness/likelihood of occurrence across the entire area of the study. A negative association between species  richness and elevation, habitat complexity and sun index indicated that richness within the study area decreases with increasing altitude, vertical vegetation structure and exposure to solar radiation. Landform  characteristics were important (to varying degrees) in determining habitat occupancy for all of the species examined, while the influence of habitat complexity was important for only one of the species. Performance of all but one of the models generated using presence/absence data was high, as indicated by the area under the curve of a receiver-operating characteristic plot. The effective conservation of the small mammal species in the area of concern is likely to depend on management actions that promote the protection of the critical habitats identified in the models.

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The shearing behavior of a drawing-steel and aluminum alloy were investigated using hardness contours of partially deformed samples and a finite element model of the trimming process. Results showed that the stress and strain distributions within the work-piece were more strongly dependent on the punch penetration than the material properties of the work-piece. Differences in the final fracture surface profile and burr formation of the drawing-steel and aluminum alloy were a consequence of the shape of the stress and strain distribution when the crack in the sample became unstable, not when it was initiated. Results and existing literature suggest that a correlation may exist between the strain-rate sensitivity of the work-piece material and the burr mechanism and fracture surface profile of the trimmed part.

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This research extends upon the previous work of Pye and Warren (2005) and presents a refinement of the previously proposed critical infrastructure model to enhance further our understanding and apprecication of where the likely inter-play and existance of dependency relationships between infrastructures coexist.

These associations are presented as a number of linkages that exist within each sector of Australia'a critical infrastructure, which is then extended further to the modelling of dependency inter-relationships that exist between critical infrastructures itilising Petri Nets.  The recognition and identification of such reliance relationships between critical infrastructures is necessary to allow both infrastructure owners and the government to identify and effectively manage and maintain the security, stability and availability of their particular critical infrastructure against potential scenario driven effects.  These issues are reflected within a case study as modelled using the Petri Net approach to encapsulate the issues of reliance relationships by drawing upon an Australian commercial case study.

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The blackwater model was developed to predict adverse water quality associated with flooding of the Barmah-Millewa Forests on the River Murray. Specifically, the model examines the likelihood and severity of blackwater events—high dissolved organic carbon associated with low dissolved oxygen. The Barmah-Millewa Forests are dominated by an overstorey of River Red Gum (Eucalyptus camaldulensis) and the litter from these trees contributes a substantial proportion of the pulse of dissolved organic matter released from the floodplain during flooding. This model examines rates of litter accumulation and decay on the floodplain (prior to and during flooding), rates of carbon leaching, microbial degradation, oxygen consumption, reaeration processes and the effects of flow on the concentrations of dissolved organic carbon and dissolved oxygen in the water column (both on the floodplain and in the river channel downstream). The model has been calibrated with data from two blackwater events that have taken place in these forests within the last 5 years. Scenario testing with the model highlights the particularly important roles of flow and temperature in the development of anoxia. Pooled floods and those in the warmest months of the year are substantially more likely to result in blackwater events than floods in cooler times of the year and involving more water exchange between the river channel and the floodplain.

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This paper reviews the evolution of Fanger's heat balance equation in regard of adaptive opportunities. Heat balance and adaptive response are integrated into one model as two fundamental aspects of human-environment interaction that define thermal comfort perception, rather than being seen as two concepts of alternative comfort paradigms. The paper suggests to extent Fanger's model with a heat storage term in order to account for comfort perception under transient thermal conditions, and to review Fanger's modelling assumptions in order to allow for a greater variety of adaptive response options. In the presented model heat exchange is modulated through adaptation of physiological, environmental and behavioural parameters in the human-environment system defined through Fanger's heat exchange equations. A computational prototype is implemented to determine 'comfortable' values and ranges of the six comfort dimensions alternatively to Fanger's comfort indices. Thereby values of for example 'comfortable' clothing and metabolic rate are results rather than necessary input parameters, which are difficult to determine. This approach allows generating design advice for physical, organisational and social environments based on heat balance calculation in the six-dimensional opportunity space defined through Fanger's comfort equation. A starting point for the development of a dynamic adaptive comfort model is set.